Pediatric Neurosurgical Patients

Effects of Positive End Expiratory Pressure (PEEP) on Intracranial and Cerebral Perfusion Pressure In Pediatric Neurosurgical Patients

Authors: Pulitanò S, Mancino A, Pietrini D, Piastra M, De Rosa S, Tosi F, De Luca D, Conti G.

BACKGROUND:: Positive end expiratory pressure (PEEP) improves oxygenation by optimizing alveolar recruitment and reducing intrapulmonary shunt. Unfortunately, PEEP can interfere with intracranial pressure (ICP) by increasing intrathoracic pressure. We hypothesized that the use of different PEEP levels could have an effect on intracranial and cerebral perfusion pressure (CPP), gas exchange, respiratory system mechanics, and hemodynamics in pediatric patients undergoing major neurosurgical procedures.

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